What is the Difference Between p53 and TP53?

The main difference between p53 and TP53 lies in their roles and the fact that one is a protein and the other is a gene. p53 is a tumor suppressor protein that plays a crucial role in regulating cell division and preventing tumor development. In contrast, TP53 is the gene that contains the genetic information to produce the p53 protein.

• p53: This protein acts as a tumor suppressor by regulating cell division and preventing cells from growing and dividing too fast or in an uncontrolled way. It also stabilizes the genome and prevents genomic mutations that can lead to the development of cancers.
• TP53: The TP53 gene provides instructions for making the p53 protein. Mutations in the TP53 gene can lead to the production of mutant p53 proteins, which can increase the risk of several types of cancer. The frequency of TP53 mutations varies greatly between different tumor types.

In summary, p53 is a tumor suppressor protein that regulates cell division and prevents tumor development, while TP53 is the gene responsible for producing the p53 protein.

Comparative Table: p53 vs TP53

p53 and TP53 refer to the same gene, but they are expressed differently. p53 is the protein encoded by the TP53 gene, which is a tumor suppressor gene. The p53 protein plays a crucial role in regulating cell division and preventing the development of cancerous cells. Here is a table comparing the differences between p53 and TP53:

It is essential to note that the information provided in the search results mainly focuses on the differences in p53 and TP53 expression and mutation detection methods, rather than discussing the differences between the two entities themselves. Since p53 is the protein encoded by the TP53 gene, they are fundamentally related and serve the same function in the cell.