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Guilherme Mazui

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What is the Difference Between Ubiquitination and SUMOylation?

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Ubiquitination and SUMOylation are two important post-translational modifications that

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  • What is the Difference Between Ubiquitination and SUMOylation?
  • Comparative Table: Ubiquitination vs SUMOylation

    • Comparative Table: Ubiquitination vs SUMOylation

    The main differences between ubiquitination and SUMOylation are their functions and the type of proteins they target. Here is a table comparing the two post-translational modifications:

    Feature Ubiquitination SUMOylation
    Function Marks proteins for degradation Does not mark proteins for degradation; regulates protein localization and activity
    Target Proteins Regulates thousands of proteins Targets specific proteins involved in various cellular processes
    Enzyme Classes Uses different enzyme classes Analogous to ubiquitination in terms of reaction scheme and enzyme classes used
    Reversibility Reversible process Reversible process

    Ubiquitination is a post-translational modification that marks proteins for degradation, while SUMOylation does not mark proteins for degradation but instead regulates protein localization and activity. Both modifications are reversible processes that involve enzyme classes. Although SUMOylation is analogous to ubiquitination in terms of reaction scheme and enzyme classes used, they differ in their functions and the type of proteins they target.

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    Guilherme Mazui

    Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.