What is the Difference Between Tylosin Tartrate and Tylosin Phosphate?

Tylosin tartrate and tylosin phosphate are both formulations of the macrolide antibiotic tylosin, which is used in veterinary medicine for its broad spectrum of activity against Gram-positive organisms and limited range against Gram-negative organisms. The key difference between the two formulations lies in their absorption after oral administration:

• Tylosin Tartrate: This formulation has a chemical formula of C50H83NO23 and a molar mass of 1066.2 g/mol. After oral administration, the calculated oral bioavailability (F) of tylosin tartrate is 25.78%.
• Tylosin Phosphate: This formulation has a chemical formula of C46H80NO21P and a molar mass of 1014.1 g/mol. After oral administration, the calculated oral bioavailability (F) of tylosin phosphate is 13.73%.

In summary, tylosin tartrate is better absorbed than tylosin phosphate after oral administration, with a higher oral bioavailability.

Comparative Table: Tylosin Tartrate vs Tylosin Phosphate

The main difference between tylosin tartrate and tylosin phosphate lies in their absorption after oral administration. Here is a table comparing the two compounds:

Tylosin tartrate and tylosin phosphate are both macrolide antibiotics derived from cultures of Streptomyces and are effective against many microorganisms in animals. However, tylosin tartrate is better absorbed than tylosin phosphate after oral administration, making it more effective in treating animal infections.