What is the Difference Between Trivalent and Quadrivalent Flu Vaccine?

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The main difference between trivalent and quadrivalent flu vaccines lies in the number of strains of the flu virus they protect against.

  • Trivalent flu vaccine: This vaccine protects against three strains of the flu, including two strains of influenza A (H1N1 and H3N2) and one strain of influenza B.
  • Quadrivalent flu vaccine: This vaccine protects against four strains of the flu, including two strains of influenza A (H1N1 and H3N2) and two strains of influenza B.

Both trivalent and quadrivalent flu vaccines are effective in providing protection against the flu, and the CDC does not currently recommend one over the other. However, the quadrivalent vaccine offers broader protection by covering both B-strains of the influenza virus. In seasons with relatively high influenza B activity, quadrivalent vaccines have been found to be more protective than trivalent vaccines.

Comparative Table: Trivalent vs Quadrivalent Flu Vaccine

The main difference between trivalent and quadrivalent flu vaccines lies in the number of virus strains they protect against. Here is a comparison table highlighting the differences:

Feature Trivalent Flu Vaccine Quadrivalent Flu Vaccine
Number of Strain