What is the Difference Between Testosterone and DHT?

Testosterone and dihydrotestosterone (DHT) are both androgens, which are hormones that stimulate the development of male characteristics. However, they have different potencies and roles in the body. Here are some key differences between testosterone and DHT:

• Potency: DHT is considered a more potent androgen than testosterone. It binds more strongly to androgen receptors and has a longer-lasting effect.
• Formation: DHT is made from testosterone by an enzyme called 5-alpha-reductase, which is mainly present in the skin, prostate, and liver.
• Roles: Testosterone plays a significant role in maintaining male physiology, while DHT does not play a significant role in adult male physiology. DHT is mainly involved in the development of sexual structures and characteristics, such as the formation of male external genitalia and the prostate. During puberty, DHT promotes the growth of facial hair and body hair.
• Medical Conditions: DHT is associated with certain medical conditions, such as male pattern hair loss, hirsutism (abnormal hair growth in females), benign prostatic hyperplasia (BPH), and prostate cancer.
• Concentration: DHT constitutes only about 10% of the circulating testosterone level in the blood, but due to its isolated production in peripheral tissues, the DHT level can be as much as ten times greater than testosterone.

In summary, testosterone and DHT are both androgens with different potencies and roles in the body. While testosterone plays a significant role in maintaining male physiology, DHT is mainly involved in the development of sexual structures and characteristics and is associated with certain medical conditions.

Comparative Table: Testosterone vs DHT

Testosterone and DHT (dihydrotestosterone) are both androgens, which are male sex hormones. They play crucial roles in male reproductive health and male body development. Here is a table comparing the differences between testosterone and DHT:

Testosterone is a less potent agonist of the androgen receptor, while DHT is a more potent agonist of the androgen receptor. DHT is primarily converted from testosterone in target organs such as the prostate, skin, and liver. Both hormones play important roles in various processes in the body, including reproduction, metabolism, and immune response.