What is the Difference Between Streptomycin and Gentamicin?

Streptomycin and gentamicin are both aminoglycoside antibiotics that function by inhibiting the 30S ribosomal subunit of bacteria, leading to the formation of an improperly functioning bacterial cell membrane. They are traditionally used as Gram-negative antibacterial medications. However, there are some differences between the two:

1. Spectrum of activity: Gentamicin is effective against both Gram-positive and Gram-negative bacteria, while streptomycin is effective only against Gram-negative bacteria, with some activity against Gram-positive bacteria.
2. Concentration: Gentamicin is typically used in lesser concentrations than streptomycin.
3. Stability: Gentamicin is highly stable in high heat and low pH, making it more effective in controlling bacterial growth in certain conditions.
4. Origin: Streptomycin is originally isolated from Streptomyces griseus, while gentamicin is derived from Micromonospora purpurea.

Both antibiotics can be used for a wide range of infectious diseases and in sterile cell cultures. They are broad-spectrum antibiotics and have no negative effect on the ribosomes of human cells. Both streptomycin and gentamicin can be administered intravenously or intramuscularly through injections, and they may have some side effects.

Comparative Table: Streptomycin vs Gentamicin

Here is a table comparing the differences between streptomycin and gentamicin:

Both streptomycin and gentamicin are aminoglycoside antibiotics used to treat a wide range of bacterial infections. They work by inhibiting the protein synthesis of bacteria and are water-soluble. Both antibiotics can be administered intravenously or intramuscularly through injections.