What is the Difference Between Steroidal and Nonsteroidal Anti inflammatory Drugs?

The main difference between steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) lies in their chemical structure and side effects. Both types of drugs are used to reduce inflammation, pain, and fever, but they work in different ways:

1. Chemical Structure: Steroidal anti-inflammatory drugs are synthetic hormones, while nonsteroidal anti-inflammatory drugs (NSAIDs) are non-narcotic pain relievers.
2. Mechanism of Action: NSAIDs work like corticosteroids without steroid side effects. They stop the body from producing certain chemicals that cause inflammation. Steroids, on the other hand, are synthetic drugs similar to cortisone, a naturally occurring hormone, and work by suppressing the immune system, which reduces inflammation.
3. Side Effects: NSAIDs are generally considered safer than steroids, with fewer side effects. Long-term use of NSAIDs can cause gastrointestinal issues such as abdominal discomfort, constipation, and nausea. Steroids have a greater risk of side effects, especially when taken for prolonged periods, as they suppress the immune system, increasing the risk of infection.
4. Examples: Common steroidal anti-inflammatory drugs include prednisone, cortisone, and hydrocortisone. Examples of NSAIDs include aspirin, ibuprofen, and naproxen sodium.

In summary, steroidal anti-inflammatory drugs are synthetic hormones that suppress the immune system to reduce inflammation, while nonsteroidal anti-inflammatory drugs work by stopping the production of inflammation-causing chemicals. Steroids tend to have more side effects than NSAIDs, which are generally considered safer for short-term use.

Comparative Table: Steroidal vs Nonsteroidal Anti inflammatory Drugs

Here is a table comparing the differences between steroidal and nonsteroidal anti-inflammatory drugs:

Corticosteroids, such as prednisone, cortisone, and methylprednisolone, are synthetic hormones that reduce inflammation through hormonal action. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin), naproxen (Aleve), and celecoxib, are non-narcotic pain relievers that reduce inflammation by blocking two forms of the cyclooxygenase enzyme (COX-1 and COX-2). Both types of drugs are prescribed to reduce inflammation in the body, but they have different mechanisms, uses, and side effects.