What is the Difference Between Saytzeff and Hofmann Rule?
🆚 Go to Comparative Table 🆚The Saytzeff rule and Hofmann rule are important in predicting the end product of an organic chemical reaction, specifically in elimination reactions involving tertiary amines and quaternary ammonium salts. The key difference between these two rules lies in the stability of the product formed:
- Saytzeff rule: This rule indicates that the more substituted product is the most stable product. In elimination reactions involving tertiary amines, the majority of the product formed is the more substituted alkene.
- Hofmann rule: This rule predicts that the least substituted product is the most stable product. In elimination reactions involving quaternary ammonium salts, the majority of the product formed is the least substituted alkene.
In summary, the Hofmann rule predicts the formation of the least substituted alkene in elimination reactions involving quaternary ammonium salts, while the Saytzeff rule predicts the formation of the more substituted alkene in elimination reactions involving tertiary amines.
Comparative Table: Saytzeff vs Hofmann Rule
The key difference between Saytzeff and Hofmann Rule lies in the stability of the products they predict. Here is a summary of their differences:
| Saytzeff Rule (Zaitsev's Rule) | Hofmann Rule |
|---|---|
| Most substituted product is the most stable | Least substituted product is the most stable |
| Applies to elimination reactions with neutral leaving groups | Applies to reactions with charged leaving groups, such as -NR3+ or -SR2+, and strong bases |
| Developed by Alexander Mikhailovich Zaitsev | Developed by August Wilhelm von Hofmann |
Both rules are used to predict the end product of an organic chemical reaction based on the substitution of the final alkene product. However, they apply to different types of reactions and predict different levels of stability for the products.
- Hofmann vs Curtius Rearrangement
- Pauli Exclusion Principle vs Hund Rule
- Markovnikov vs Anti-Markovnikov Rule
- Sandmeyer Reaction vs Gattermann Reaction
- Mohr Volhard vs Fajans Method
- Hartree vs Hartree-Fock Method
- Ising vs Heisenberg Model
- Schiff Base vs Schiff’s Reagent
- Finkelstein vs Swarts Reaction
- Regime vs Rule
- Hall Héroult Process vs Hoopes Process
- Wittig vs Wittig Horner Reaction
- Tay-Sachs vs Sandhoff Disease
- Gibbs Free Energy vs Helmholtz Free Energy
- Heck Stile vs Suzuki Reaction
- Bohr Effect vs Haldane Effect
- Embden Meyerhof Pathway vs Entner Doudoroff Pathway
- Bohr vs Schrodinger Model
- Rutherford vs Bohr