What is the Difference Between Reversion and Suppression Mutation?
🆚 Go to Comparative Table 🆚The main difference between reversion and suppression mutation lies in the mechanisms through which they occur and their effects on the original mutation:
- Reversion Mutation:
- Reversion mutation is a change in the nucleotide sequence that restores the original base sequence of the gene, reversing the effect of the first mutation.
- It results in the resumption of the activity of the wild-type gene, returning the phenotype to its original state.
- Reversion mutations can occur due to the loss of a controlling element or through a suppression mutation.
- Suppression Mutation:
- Suppression mutation is a mutation that suppresses the phenotypic effect of the original mutation, restoring the gene activity in which the first mutation occurred.
- It can be intragenic (occurring within the same gene as the original mutation) or intergenic (occurring in a different gene).
- Suppressor mutations can vary depending on the original mutation and may involve mechanisms such as restoration of reading frame, correction of protein folding to reduce degradation rates, or changing protein conformation to allow catalytic activity.
In summary, reversion mutations restore the original base sequence of the gene and its function, while suppression mutations change the phenotypic effect of the original mutation without necessarily restoring the original base sequence. Additionally, reversion mutations can be caused by suppression mutations, further differentiating the two types of mutations.
On this pageWhat is the Difference Between Reversion and Suppression Mutation? Comparative Table: Reversion vs Suppression Mutation
Comparative Table: Reversion vs Suppression Mutation
Here is a table highlighting the differences between reversion and suppression mutations:
| Feature | Reversion Mutation | Suppression Mutation |
|---|---|---|
| Definition | A mutation that reverses the effect of the first mutation, restoring the original base sequence of the gene and resuming the activity of the wild-type gene. | A mutation that suppresses the phenotypic effect of the first gene, restoring the gene activity in which the first mutation occurred. It can be intragenic or intergenic. |
| Types | Intragenic reversion (within the gene) and intergenic (extragenic) reversion (outside the gene). | Intragenic suppression mutation (within the same gene as the original mutation) and intergenic (extragenic) suppression mutation (in a different gene compared to the site of the original mutation). |
| Mechanism | Reversion mutation occurs if the mutant gene and suppressor are in close proximity, and the original base sequence can be restored. | Suppression mutation can be intragenic (same-site replacement, compensatory mutation, alteration in splicing, reversion of dominant mutations by cis-knockout) or intergenic (alterations in splicing, changes in the cell's translational machinery). |
| Examples | Reversion can occur by mutating the sequence back to the wild-type sequence or by a different base change that results in a functional coding sequence. | Suppression can occur by alterations in splicing, changes in the cell's translational machinery, or by mutations in tRNA or ribosomal genes. |
Please note that reversion mutation is a specific type of suppression mutation, so the two concepts are related.
Read more:
- Back Mutation vs Suppressor Mutation
- Forward vs Reverse Mutation
- Intragenic vs Extragenic Suppressor Mutation
- Mutation vs Recombination
- Substitution Insertion vs Deletion Mutations
- Mutation vs Mutagen
- SNP vs Mutation
- Oncogene vs Tumor Suppressor Gene
- Repression vs Suppression
- Synonymous vs Nonsynonymous Mutation
- Missense vs Nonsense Mutation
- Silent vs Neutral Mutation
- Mutation Rate vs Substitution Rate
- Spontaneous vs Induced Mutation
- Point Mutation vs Chromosomal Mutation
- Frameshift Mutation vs Point Mutation
- Frameshift Mutation vs Base Substitution Mutation
- DNA Damage vs Mutation
- Germline Mutation vs Somatic Mutation