What is the Difference Between Promethazine Hydrochloride and Theoclate?

Promethazine hydrochloride and promethazine teoclate are both derivatives of promethazine, a phenothiazine compound with antiemetic and antihistamine properties. The key difference between the two is the addition of diphenhydramine and theophylline to promethazine teoclate.

• Promethazine hydrochloride: This is a first-generation antihistamine and antiemetic medication used to treat insomnia, nausea, and symptoms associated with a common cold. It is available as tablets in two strengths (10mg and 25mg) and as an elixir. Promethazine hydrochloride is licensed for use in adults and children from the age of two years.
• Promethazine teoclate: This medication is a combination of promethazine, diphenhydramine, and theophylline. It is used to treat nausea and vomiting related to certain conditions such as surgery or motion sickness. Promethazine teoclate is licensed for adults and children from the age of five years.

Both promethazine hydrochloride and promethazine teoclate have marked anti-motion sickness activity and antimuscarinic properties, causing sedation as a common side effect. Anecdotal evidence suggests that promethazine teoclate is well tolerated and causes less drowsiness than promethazine maleate (Phenergan).

Comparative Table: Promethazine Hydrochloride vs Theoclate

Here is a table comparing the differences between promethazine hydrochloride and promethazine theoclate:

Promethazine hydrochloride is a medication used to treat and prevent nausea and vomiting, including those related to surgery and motion sickness, as well as to treat allergy symptoms. Promethazine theoclate, on the other hand, is a combination of promethazine, diphenhydramine, and theophylline, and is used as a long-acting anti-motion sickness medication. Both medications are phenothiazines with marked anti-motion sickness activity and antimuscarinic properties, and they can cause sedation.