What is the Difference Between Prednisone and Prednisolone?

Prednisone and prednisolone are both synthetic glucocorticoids used to suppress the immune system and inflammation, and they are generally considered equally effective. They are used to treat similar conditions, such as allergies, arthritis, inflammatory bowel disease, lung conditions, or skin problems. However, there are some differences between the two:

1. Conversion: Prednisone must be converted by liver enzymes to prednisolone before it can work. This means that prednisolone is the active metabolite of prednisone.
2. Liver Disease: In people with severe liver disease, prednisolone is usually preferred.
3. Dosage: Prednisolone is comparable to prednisone on an mg-to-mg basis. However, prednisolone is available in higher dose tablets, making the administration of higher doses less cumbersome.
4. Price: Prednisone is usually cheaper than prednisolone.
5. Brand Names: Brand names for prednisone include Rayos, Prednisone Intensol, and Millipred, while brand names for prednisolone include Flo-Pred, Pediapred, Orapred, and Orapred ODT.

Both prednisone and prednisolone have similar side effects, including acne, stomach irritation, weight gain, insomnia, fluid retention, facial hair growth, mood changes, and more. They also have similar interactions with other medications, such as NSAIDs and anti-infectives. Dosing schedules for both medications are usually similar, ranging from 5mg to 60mg.

Comparative Table: Prednisone vs Prednisolone

Prednisone and prednisolone are both synthetic glucocorticoids used to treat similar conditions, such as inflammation and autoimmune diseases. However, there are some differences between the two medications:

Both prednisone and prednisolone have similar side effects, interactions, and dosing schedules. They are also available in generic versions and brand names, such as Prednisone Intensol® and Millipred® for prednisolone.