What is the Difference Between Pertussis and Tuberculosis?

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Pertussis and tuberculosis are two different infectious diseases that affect the respiratory system. They have distinct characteristics, causes, and treatments. Here are the main differences between the two:

  1. Causative agents: Pertussis is caused by the bacterium Bordetella pertussis, while tuberculosis is caused by Mycobacterium tuberculosis.
  2. Disease progression: Pertussis is an acute disease with specific endpoints, whereas tuberculosis is a more chronic disease that may take years before it manifests and becomes recognized.
  3. Nature of the disease: Pertussis, also known as whooping cough, is exclusively a respiratory disease, while tuberculosis is a multisystemic disease that primarily affects the lung tissue but can also affect other organs.
  4. Symptoms: Although both diseases may present with common symptoms such as cough, sneezing, stuffy nose, headaches, muscle aches, wheezing, high temperature, and feeling unwell, tuberculosis may also involve complications like arthritis, back pain, stiffness, meningitis, miliary TB, heart disorders, lymphadenitis, and intestinal TB.
  5. Treatment: Both diseases can be treated through antibiotics, but the specific drugs used may vary. For example, tuberculosis treatment may include antibiotics such as isoniazid, rifampin, ethambutol, pyrazinamide, fluoroquinolones, amikacin or capreomycin, bedaquiline, linezolid, and a vaccine called Bacillus Calmette–Guérin (BCG).
  6. Mortality: Tuberculosis is a more severe disease, causing approximately 2 million deaths per year, while pertussis is responsible for around 300,000 annual deaths.
  7. Demographics: Pertussis-related deaths mostly occur in young children (around 95% in children less than 6 months of age), whereas tuberculosis affects both developing and industrialized countries.

In summary, pertussis and tuberculosis are two distinct respiratory diseases with different causative agents, disease progression, and treatment options. Pertussis is an acute, exclusively respiratory disease, while tuberculosis is a chronic, multisystemic disease that tends to be more severe and has a higher mortality rate.

Comparative Table: Pertussis vs Tuberculosis

Here is a table comparing the differences between pertussis and tuberculosis:

Feature Pertussis Tuberculosis
Caused by Bordetella pertussis Mycobacterium tuberculosis
Affected organs Mainly affects the respiratory system Primarily affects the lung tissue, but can also affect various organs, making it a multisystemic disease
Contagiousness Highly contagious Less contagious than pertussis
Symptoms Cough, sneezing, stuffy nose, headaches, muscle aches, wheezing, high temperature, and feeling unwell Cough, sneezing, stuffy nose, headaches, muscle aches, wheezing, high temperature, and feeling unwell
Complications Bruised, broken ribs, subconjunctival hemorrhage or bloodshot eyes, pneumonia, apnea, seizures, abdominal hernias, and cerebral tissue damage Arthritis, back pain, stiffness, meningitis, miliary TB, heart disorders, lymphadenitis, and intestinal TB
Diagnosis Cultures of nasopharyngeal specimens, specific fluorescent antibody testing of nasopharyngeal smears, and polymerase chain reaction (PCR) assay Physical examination, tuberculin skin test, blood test, imaging test (X-ray and CT scan), and sputum test
Treatment Antibiotics Antibiotics such as isoniazid, rifampin, ethambutol, pyrazinamide, fluoroquinolones, amikacin or capreomycin, bedaquiline, linezolid, and a vaccine called Bacillus Calmette–Guérin (BCG)

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