What is the Difference Between Periosteal and Parosteal Osteosarcoma?

The main differences between periosteal and parosteal osteosarcoma are their origins, radiological features, histological grade, and prognosis. Here are the key differences:

Origin: Periosteal osteosarcoma arises from under the periosteum, while parosteal osteosarcoma arises on the surface of the bone.
Radiological Features: Periosteal osteosarcoma typically presents with periosteal elevation, while parosteal osteosarcoma has a densely ossified mass radiologically.
Histological Grade: Periosteal osteosarcoma is of intermediate grade, while parosteal osteosarcoma is well-differentiated (Grade 1 or 2).
Prognosis: Periosteal osteosarcoma has a better prognosis than conventional osteosarcoma but not as good as parosteal osteosarcoma. Parosteal osteosarcoma has a low-grade histological picture and is considered a slow-growing tumor.

In summary, periosteal osteosarcoma arises from under the periosteum, has an intermediate histological grade, and a better prognosis than conventional osteosarcoma. In contrast, parosteal osteosarcoma arises on the surface of the bone, has a well-differentiated histological grade, and a more favorable prognosis.

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What is the Difference Between Periosteal and Parosteal Osteosarcoma?

Comparative Table: Periosteal vs Parosteal Osteosarcoma

Here is a table comparing the differences between periosteal and parosteal osteosarcoma:

Feature	Periosteal Osteosarcoma	Parosteal Osteosarcoma
Definition	A high-grade osteosarcoma that arises from the periosteum below the surface of the bone	A low-grade osteosarcoma that arises from the periosseous tissues adjacent to the cortex
Age of Onset	Tends to occur at a younger age, with a mean age of 20 years in one study	Generally affects younger patients, often in their 20s
Radiological Appearance	Characterized by periosteal elevation and nonhomogeneous calcified spiculations perpendicular to the cortex, giving a "sunburst appearance"	Rarely presents with periosteal elevation
Histological Grade	Intermediate or higher-grade osteosarcoma	Lower-grade osteosarcoma
Treatment	Wide resection with limb salvage is the surgical treatment of choice	Chemotherapy and radiotherapy are generally not very effective

Please note that these are general characteristics and may not apply to every case of periosteal or parosteal osteosarcoma.

Guilherme Mazui

Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.