What is the Difference Between Parafollicular and Follicular Cells?

Parafollicular and follicular cells are both present in the thyroid gland, but they have distinct functions, structures, and developmental origins.

Parafollicular Cells:

• Also known as C cells.
• Neuroendocrine cells.
• Primary function is to secrete calcitonin, a hormone that regulates calcium metabolism.
• Larger and paler than follicular cells.
• Derived from pharyngeal endoderm.

Follicular Cells:

• Line the thyroid follicles.
• Primary function is to secrete thyroxine (T4) and triiodothyronine (T3), hormones that influence the rate of metabolism.
• Size varies depending on the stage of follicular activity.
• Derived from the endoderm.

In summary, the key difference between parafollicular and follicular cells is their function. Parafollicular cells secrete calcitonin, while follicular cells secrete thyroxine and triiodothyronine. Additionally, parafollicular cells are larger and have a different shape compared to follicular cells.

Comparative Table: Parafollicular vs Follicular Cells

Here is a table summarizing the differences between parafollicular and follicular cells:

Parafollicular cells, also known as C cells, secrete calcitonin, which is important for calcium regulation in the body. On the other hand, follicular cells secrete thyroxine (T4) and triiodothyronine (T3), hormones that control the body's growth, development, and metabolism.