What is the Difference Between Oxidative and Nonoxidative Deamination?

The main difference between oxidative and nonoxidative deamination lies in the type of chemical reaction involved in the removal of amine groups from amino acids.

Oxidative deamination:

• Involves the oxidation of amino group amino acids.
• Occurs mainly in the liver and kidney.
• Primarily occurs in the form of glutamate deamination, with glutamate dehydrogenase being the enzyme responsible.
• Produces α-keto acids and other oxidized products.

Nonoxidative deamination:

• Occurs via other reactions that are not oxidation reactions, such as hydrolysis, reduction, or intramolecular reactions.
• Occurs in other organs besides the liver and kidney.
• Involves hydroxyl amino acids undergoing deamination, such as serine, homoserine, and threonine.
• Primarily occurs in the form of amino acid dehydratases.

In summary, oxidative deamination involves oxidation reactions and mainly occurs in the liver and kidney, while nonoxidative deamination takes place through hydrolysis, reduction, or intramolecular reactions in other organs.

Comparative Table: Oxidative vs Nonoxidative Deamination

Here is a table comparing the differences between oxidative and nonoxidative deamination:

In summary, the main difference between oxidative and nonoxidative deamination is the presence or absence of oxidation. Oxidative deamination occurs in the liver and kidney and is catalyzed by glutamate dehydrogenase and monoamine oxidase, while nonoxidative deamination occurs in other organs and is catalyzed by lyases, amino acid dehydratases, and sulfhydrylases.