What is the Difference Between Nifedipine and Amlodipine?

Nifedipine and amlodipine are both calcium channel blockers used for the treatment of hypertension (high blood pressure). They have some differences in their properties and effects:

1. Duration of action: Nifedipine is a relatively short-acting medication, requiring two or three times daily administration. On the other hand, amlodipine is a long-acting calcium antagonist. In a study comparing the two drugs, amlodipine given once daily was found to be at least as effective as nifedipine tablets given twice daily.
2. Effectiveness: In some studies, amlodipine has been shown to be slightly more effective than nifedipine in lowering blood pressure, particularly in terms of supine systolic blood pressure. However, other studies have reported comparable efficacy between the two drugs.
3. Tolerability: Amlodipine has been found to be better tolerated than nifedipine, with a lower incidence of side effects. For example, headache, flushing, and dizziness were reported more frequently by patients while on nifedipine retard than on amlodipine.
4. Side effects: The incidence of edema (swelling) has been reported to be greater in the amlodipine-treated group, while nifedipine has been associated with a higher risk of rapid blood pressure drop.

In conclusion, both nifedipine and amlodipine are effective in treating hypertension, but they differ in their duration of action, effectiveness, and tolerability. Amlodipine is generally considered to have a longer-lasting effect and better tolerability than nifedipine, but the choice between the two medications should be based on individual patient factors and the healthcare provider's recommendation.

Comparative Table: Nifedipine vs Amlodipine

Nifedipine and amlodipine are both calcium channel blockers used for the treatment of hypertension and angina. Here is a table comparing their differences:

In conclusion, amlodipine given once daily is at least as effective as nifedipine tablets given twice daily. Amlodipine also provides improved compliance, better 24-hour BP control, and fewer adverse events than nifedipine.