What is the Difference Between Naproxen and Naproxen Sodium?

The main difference between naproxen and naproxen sodium lies in their absorption and bioavailability. Both naproxen and naproxen sodium are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat various inflammatory conditions, but they differ in their salt form and solubility.

• Naproxen: This is the base form of the drug and has a molecular formula of C14H14O3. It is available in regular tablets, enteric-coated tablets, and suspension.
• Naproxen Sodium: This is the salt form of naproxen and has a molecular formula of C14H13NaO3. It is more rapidly absorbed than naproxen and has a faster onset of action. Over-the-counter (OTC) naproxen sodium is available in 220 mg tablets.

The body reaches peak levels of naproxen in 2-4 hours and naproxen sodium in 1-2 hours, meaning that naproxen sodium is absorbed more rapidly than regular naproxen. For example, 275 mg of naproxen sodium is equivalent to 250 mg of naproxen base. However, both the base and salt forms work the same way to relieve pain.

Comparative Table: Naproxen vs Naproxen Sodium

The main difference between naproxen and naproxen sodium lies in their absorption and concentration in the body. Here is a table comparing the two:

Both naproxen and naproxen sodium belong to the group of nonsteroidal anti-inflammatory drugs (NSAIDs) and are used to relieve pain from various conditions, including arthritis, muscle aches, strains, sprains, headaches, dental pain, menstrual cramps, and fever. They work in a similar way to provide pain relief, but naproxen sodium is more rapidly absorbed compared to regular naproxen.