What is the Difference Between Missense and Nonsense Mutation?
🆚 Go to Comparative Table 🆚The main difference between missense and nonsense mutations lies in their effects on the protein they produce. Here's a comparison of the two types of mutations:
- Missense Mutation: This type of mutation occurs when there is a single change in the DNA base pair, leading to the replacement of one amino acid with another in the protein. The alteration can have no effect on the protein's function, enhance its function, or render it "faulty". In some cases, missense mutations can be classified as silent mutations if the change in the amino acid does not affect the protein's overall function.
- Nonsense Mutation: Unlike missense mutations, nonsense mutations involve a single change in the DNA base pair that produces a stop codon, prematurely terminating protein synthesis. This results in an abnormally shortened protein, which can severely affect its function.
In summary:
- Missense mutations change an amino acid in the protein, with varying effects on protein function.
- Nonsense mutations introduce a stop codon, prematurely terminating protein synthesis and leading to an abnormally shortened protein.
On this pageWhat is the Difference Between Missense and Nonsense Mutation? Comparative Table: Missense vs Nonsense Mutation
Comparative Table: Missense vs Nonsense Mutation
Here is a table comparing the differences between missense and nonsense mutations:
| Feature | Missense Mutation | Nonsense Mutation |
|---|---|---|
| Description | Substitution of one amino acid for another in a protein sequence due to a single nucleotide change | Introduction of a premature stop codon in the DNA sequence, resulting in a truncated protein |
| Effect on Protein Function | The change in amino acid can be neutral, beneficial, or detrimental to the protein's function | The truncated protein is typically non-functional or has a different function compared to the original |
| Conservative vs. Non-conservative | Missense mutations can be classified as conservative (similar amino acid properties) or non-conservative (different amino acid properties) | Nonsense mutations are not classified as conservative or non-conservative |
| Examples of Diseases | Missense mutations can lead to genetic disorders such as Duchenne Muscular Dystrophy, Dravet syndrome, and Hurler syndrome | Nonsense mutations can lead to sickle-cell disease, Mediated Amyotrophic Lateral Sclerosis (ALS), and Epidermolysis bullosa |
Please note that the effects of these mutations on proteins and their functions can vary greatly depending on the specific gene and organism involved.
Read more:
- Synonymous vs Nonsynonymous Mutation
- SNP vs Mutation
- Silent vs Neutral Mutation
- Frameshift Mutation vs Point Mutation
- Mutation vs Mutagen
- Germline Mutation vs Somatic Mutation
- Point Mutations vs Indels
- Frameshift Mutation vs Base Substitution Mutation
- Spontaneous vs Induced Mutation
- DNA Damage vs Mutation
- Mutation vs Polymorphism
- Gene Mutation vs Chromosome Mutation
- Substitution Insertion vs Deletion Mutations
- Original vs Mutated Sequences
- Nondisjunction vs Translocation Mutations
- Reversion vs Suppression Mutation
- Mutation Rate vs Substitution Rate
- Point Mutation vs Chromosomal Mutation
- Wild Type vs Mutant Type