What is the Difference Between Male and Female Fetus?

There are several differences between male and female fetuses, which can be observed during prenatal development. Some of the key differences include:

1. Size: Male fetuses are larger than female fetuses, with differences in weight and biometric indices evident from the early stages of pregnancy. For example, the crown-rump length is larger in male fetuses compared to females in the first trimester.
2. Growth Pattern: The growth pattern of the head circumference differs with fetal sex, with male fetuses having a larger head circumference than female fetuses.
3. Immune Response: Male fetuses show a more pro-inflammatory immune response across gestation compared to female fetuses.
4. Placental Differences: Placentae of male and female fetuses have different protein and gene expressions, which may contribute to the differences in growth and development between the sexes.
5. Risk of Preterm Birth: Male fetuses are at a higher risk of infection leading to preterm birth and other pregnancy complications.

These differences arise due to the presence of different sex chromosomes in male and female fetuses. Males have a set of XY chromosomes, while females have a set of XX chromosomes. These sex chromosomes determine whether the embryo develops as a male or female and influence various aspects of fetal development.

Comparative Table: Male vs Female Fetus

The differences between male and female fetuses in terms of growth patterns and body proportions are sex-specific. Some of the key differences include:

• Anogenital Distance (AGD): The AGD is the distance between the tail-like end of the fetus and the genital base of the tubercle. In male fetuses, the AGD is larger than in female fetuses, and it is dependent on testosterone levels.

• Biparietal Diameter (BPD): Female fetuses have been found to have significantly smaller mean BPD at 18-21 weeks of gestation.

• Crown-Rump Length (CRL): In one study, the average CRL of female fetuses (46.88 ± 2.65 mm) was found to be slightly shorter than that of male fetuses (49.68 ± 2.67 mm), although the difference was not significant.

A table summarizing these differences is below:

These differences can be attributed to the effects of sex hormones during early fetal development. It is essential to consider these sex-specific differences when assessing fetal growth and development patterns.