What is the Difference Between Leydig Cells and Sertoli Cells?

Leydig cells and Sertoli cells are both found in the testes and play crucial roles in male reproductive function, particularly in spermatogenesis and hormonal regulation. However, they have distinct roles and characteristics:

Leydig Cells:

• Found in the interstitium outside the seminiferous tubules.
• Produce androgens, including testosterone, androstenedione, and dehydroepiandrosterone (DHEA).
• Testosterone levels are higher inside the testes compared to the serum.
• Under hormonal regulation by the hypothalamic-pituitary axis.
• Round in shape and present as small groups within a shorter distance to each other.

Sertoli Cells:

• Found specifically in the convoluted seminiferous tubules.
• Required for testicular development and spermatogenesis.
• Also known as mother or nursing cells because they offer sustenance to growing germ cells.
• Function as phagocytes, consuming cytoplasm left over during spermatogenesis.
• Secrete inhibin, ABP (Aromatase Binding Protein), and anti-Mullerian hormone.
• Tall and elongated in shape, and present as single cells which are tightly packed.

In summary, Leydig cells are responsible for producing androgens, while Sertoli cells support the development and maturation of sperm cells. Both cell types play essential roles in maintaining spermatogenesis, controlling hormonal regulation, and affecting secondary sexual characteristics in males.

Comparative Table: Leydig Cells vs Sertoli Cells

Here is a table highlighting the differences between Leydig cells and Sertoli cells:

Leydig cells and Sertoli cells are both essential components of the male reproductive system, playing crucial roles in spermatogenesis and hormone production.