What is the Difference Between Lac and Trp Operon?

🆚 Go to Comparative Table 🆚

The Lac operon and Trp operon are two well-studied operons in bacteria that play crucial roles in gene regulation. They differ in their regulatory mechanisms and the molecules they encode.

  • Lac Operon: This operon is an inducible operon that encodes enzymes for the metabolism of the sugar lactose. It is normally turned off and only turns on when lactose is present and other preferred sugars are absent. The inducer in this case is allolactose, a modified form of lactose.
  • Trp Operon: This operon is a repressible operon that encodes enzymes for the synthesis of the amino acid tryptophan. It is expressed by default and can be turned off by a small molecule called a corepressor. Tryptophan acts as a co-repressor, binding to the Trp repressor and inhibiting the operon's expression.

In summary, the main differences between the Lac and Trp operons are:

  1. The Lac operon is inducible, while the Trp operon is repressible.
  2. The Lac operon encodes enzymes for lactose metabolism, while the Trp operon encodes enzymes for tryptophan synthesis.
  3. The Lac operon is regulated by the inducer allolactose, while the Trp operon is regulated by the corepressor tryptophan.

Comparative Table: Lac vs Trp Operon

Here is a table comparing the differences between the lac and trp operons:

Feature Lac Operon Trp Operon
Type of Operon Inducible Repressible
Function Involved in the catabolic process of a sugar Involved in the anabolic process of an amino acid
Activation/Deactivation Activated in the presence of lactose Deactivated in the presence of tryptophan
Structure Consists of three structural genes and a repressor gene Consists of five structural genes and a repressor gene
Mechanism Does not use the "attenuation" mechanism Uses the "attenuation" mechanism

The lac operon is an inducible system, meaning it is only activated in the presence of lactose, while the trp operon is a repressible system, meaning it is normally turned on and only deactivated in the presence of tryptophan.