What is the Difference Between L Glutathione and S Acetyl Glutathione?

The main difference between L-glutathione and S-acetyl glutathione lies in their structure and absorption. Here are the key differences:

1. Isomerism: L-glutathione is an isomer of glutathione, specifically the L-isomer, and is in a non-acetylated form. On the other hand, S-acetyl glutathione is an acetylated form of glutathione.
2. Absorption: Unlike L-glutathione, which is broken down into its amino acid components by peptidases in the blood and has poor oral absorption, S-acetyl glutathione is well-absorbed orally and is not affected by peptidases in the blood. It is absorbed intact into the cell, where the acetyl group is cleaved off, producing an intact glutathione molecule.

Both L-glutathione and S-acetyl glutathione are forms of glutathione, a powerful antioxidant that helps protect the body from damage caused by free radicals. However, S-acetyl glutathione has been shown to be more efficient and better absorbed than regular glutathione.

Comparative Table: L Glutathione vs S Acetyl Glutathione

L-glutathione and S-acetyl glutathione are two forms of glutathione, a powerful antioxidant produced in the body. Here is a table comparing their differences:

L-glutathione is the non-acetylated form of glutathione, while S-acetyl glutathione is an acetylated form of glutathione. When taken orally, L-glutathione is less stable and has limited absorption, whereas S-acetyl glutathione is more stable and easily absorbed. Both forms provide antioxidant benefits, but S-acetyl glutathione offers enhanced bioavailability, making it more effective in supporting immune function and cellular protection.