What is the Difference Between Inactivated and Recombinant Flu Vaccine?

The main difference between inactivated and recombinant flu vaccines lies in the production process and the components of the vaccines. Here are the key differences:

1. Production Process: Inactivated flu vaccines are produced using an egg-based manufacturing process, which has been used for more than 70 years. In contrast, recombinant flu vaccines are created synthetically using recombinant technology, without the need for chicken eggs.
2. Components: Inactivated flu vaccines contain killed influenza viruses or their components, such as viral proteins. Recombinant flu vaccines, on the other hand, do not use the flu virus or chicken eggs in their production. Instead, they are produced by isolating a specific gene from a naturally occurring "wild type" recommended vaccine virus and combining it with a baculovirus.
3. Egg-Free: Recombinant flu vaccines are considered egg-free, making them a suitable option for individuals with egg allergies.
4. Potential Benefits: Recombinant flu vaccines have some possible advantages over inactivated flu vaccines, such as being independent of the selection of vaccine viruses adapted for growth in eggs and avoiding mutations that can occur when viruses are grown in eggs. This can sometimes affect the effectiveness of the finished vaccine.

Both inactivated and recombinant flu vaccines are designed to provide protection against influenza, but they differ in their production methods and components. The choice of which vaccine to receive depends on individual preferences and recommendations from healthcare providers.

Comparative Table: Inactivated vs Recombinant Flu Vaccine

Here is a table comparing the differences between inactivated and recombinant flu vaccines:

Inactivated flu vaccines are produced using either egg-based or cell-based technology, while recombinant flu vaccines are produced synthetically using recombinant technology. Inactivated vaccines require the use of chicken eggs or animal cells, whereas recombinant vaccines do not. Recombinant flu vaccines have the potential to be more effective than standard dose unadjuvanted flu vaccines in certain age groups.