What is the Difference Between Frontline and Frontline Plus?

🆚 Go to Comparative Table 🆚

Frontline and Frontline Plus are both flea and tick prevention products for pets, but they have some differences in their formulations and effectiveness. The main differences between Frontline and Frontline Plus are:

  1. Active Ingredients: Frontline Original contains Fipronil as its active ingredient, which is effective against adult fleas, flea allergy dermatitis, ticks, and biting lice. Frontline Plus, on the other hand, contains an additional ingredient called Methoprene, which kills all stages of the flea lifecycle, including flea eggs, larvae, and adult fleas.
  2. Flea Protection: Frontline Original protects your pet against adult fleas only, while Frontline Plus provides protection against all stages of the flea lifecycle, including flea eggs, larvae, and adult fleas.
  3. Tick Protection: Both products are effective against ticks, but Frontline Original is specifically mentioned to protect against paralysis ticks and brown dog ticks.
  4. Methoprene: Frontline Plus contains Methoprene, an ingredient that sterilizes female fleas, preventing them from laying eggs and therefore breaking the flea lifecycle.

In summary, Frontline Plus offers more comprehensive protection against fleas and ticks due to its additional active ingredient, Methoprene. Both products are effective in protecting pets from fleas, ticks, and lice, but Frontline Plus provides a broader range of protection by targeting all stages of the flea lifecycle.

Comparative Table: Frontline vs Frontline Plus

There is no information available specifically comparing Frontline and Frontline Plus. However, there is information comparing Frontline Plus with other flea treatments. Here is a table comparing Frontline Plus with one of its alternatives, Revolution:

Feature Frontline Plus Revolution
Availability Over-the-counter Prescription-only
Active Ingredient Fipronil and (S)-methoprene Selamectin
Target Pests Fleas, ticks Fleas, ticks, heartworms, and intestinal worms
Waterproof Yes Yes
Safe for Lactating, pregnant, or breeding dogs, puppies (from 8 weeks) Lactating, pregnant, or breeding dogs, puppies (from 6 weeks)
Flea Killing Time Up to 4 hours Within 12 hours
Tick Killing Time Not specified Within 12 hours
Egg and Larvae Inhibition Yes Yes
Flea and Tick Treatment Monthly Monthly
Veterinarian Prescription Not required Required

Both Frontline Plus and Revolution are waterproof topical treatments for fleas and ticks, and they are safe for use on lactating, pregnant, or breeding dogs and puppies. However, Revolution is a prescription-only medication, while Frontline Plus is available without a prescription. Revolution contains Selamectin as its active ingredient, compared to Frontline Plus's Fipronil and (S)-methoprene. Revolution is also effective against heartworms and intestinal worms, unlike Frontline Plus.