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Guilherme Mazui

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What is the Difference Between Fixation and Stabilization?

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The key difference between fixation and stabilization lies in their purposes and methods. Here is a comparison between the two processes:

Fixation:

  1. Involves the rapid penetration of fixation reagent into tissues.
  2. Aims to preserve tissue structure and prevent decay by cross-linking proteins and other biomolecules.
  3. Factors affecting fixation include hydrogen ion concentration, temperature, penetration, osmolality, and concentration duration.
  4. Can use both heat treatment methods and chemical methods, such as coagulant and non-coagulant chemicals.

Stabilization:

  1. An analytical process that stops the fixation process and optimally protects the tissue sample.
  2. Occurs after the fixation step.
  3. Involves freezing to low temperatures and using stabilizers, such as PAXgene Tissue Stabilizer, to protect tissue samples for about 7 days at room temperature.

In summary, fixation is a process used to preserve tissue structure and prevent decay, while stabilization is an analytical process that stops the fixation process and optimally protects the tissue sample.

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  • What is the Difference Between Fixation and Stabilization?
  • Comparative Table: Fixation vs Stabilization

    • Comparative Table: Fixation vs Stabilization

    Fixation and stabilization are two different concepts, but they share some similarities. Here is a table highlighting the differences between them:

    Feature Fixation Stabilization
    Definition Fixation refers to the ability of the eyes to hold the image of an object on the fovea by maintaining a constant steady gaze on the fixation point. Stabilization refers to the process of making something stable or firm, often in the context of a mechanical or structural system.
    Application Fixation is primarily used in the context of ocular motility and visual function, such as measuring fixation stability and phoria during binocular viewing. Stabilization is often used in the context of orthopedic surgery, such as medial opening wedge high tibial osteotomy, where fixation devices are employed to stabilize the bone.
    Measurement Fixation stability can be quantified using methods such as the bivariate contour ellipse area (BCEA), which calculates the area encompassing a given proportion of all fixation points. Stabilization is typically assessed by evaluating the performance of fixation devices in maintaining the stability of a structure, such as a bone, under various conditions.
    Goal The goal of fixation is to maintain a clear and steady image on the retina, which is essential for good visual function. The goal of stabilization is to provide support and stability to a structure, such as a bone, to facilitate healing and prevent complications.

    In summary, fixation is related to the stabilization of images on the retina, while stabilization is concerned with the support and maintenance of structural integrity in various contexts.

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    Guilherme Mazui

    Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.