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Guilherme Mazui

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What is the Difference Between Ferritin and Transferrin?

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Ferritin and transferrin are two proteins that play important roles in iron storage and transport in the body. The main differences between them are:

  1. Function: Ferritin is a protein that stores iron in the blood, while transferrin is a protein that transports iron in the blood and other bodily fluids.
  2. Iron Binding: Ferritin can store iron that can be released under control, whereas transferrin is involved in controlling the level of iron in biological fluids by binding to iron and transporting it to various organs.
  3. Structure: Transferrin has 679 amino acids along with two carbohydrate chains and contains both the alpha-helix form and beta-sheet form. It also has an iron-binding receptor and is associated with the innate immune system.
  4. Measurement: Ferritin levels are used to assess body iron stores, while transferrin levels, along with iron levels, are used to calculate the total iron-binding capacity (TIBC), which indicates iron deficiency or iron overload.

In summary, ferritin is primarily responsible for storing iron, while transferrin is responsible for transporting iron in the blood. Both proteins play crucial roles in maintaining proper iron levels and preventing anemia or iron deficiency.

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  • What is the Difference Between Ferritin and Transferrin?
  • Comparative Table: Ferritin vs Transferrin

    • Comparative Table: Ferritin vs Transferrin

    Here is a table comparing the differences between ferritin and transferrin:

    Feature Ferritin Transferrin
    Definition Ferritin is a protein that stores iron in the blood. Transferrin is a protein that transports iron in the blood.
    Function Stores iron in a non-toxic form, allowing it to be directly transported to the required areas of the body. Binds iron tightly but reversibly, controlling the level of iron in biological fluids such as blood.
    Iron Binding Binds and stores iron in a non-toxic form. Binds iron tightly but reversibly, controlling the level of iron in biological fluids such as blood.
    Produced in Produced by almost all cells in response to increased iron levels. Mainly produced in the liver, with trace amounts produced in other organs like the brain.
    Levels Ferritin levels are low when there is iron deficiency and high when there is an excess of iron in the body. Transferrin levels are not specific for iron deficiency and can be influenced by other factors.

    Ferritin and transferrin are two important proteins in the blood that play crucial roles in iron storage and transport, respectively. They help maintain the body's iron levels and prevent iron deficiency or overload.

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    Guilherme Mazui

    Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.