What is the Difference Between Excitatory and Inhibitory Neurotransmitters?

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Excitatory and inhibitory neurotransmitters are chemical messengers that play crucial roles in neural communication. They affect neurons in different ways, with excitatory neurotransmitters increasing the likelihood of a neuron firing an action potential, while inhibitory neurotransmitters decrease the likelihood of such firing. Some key differences between excitatory and inhibitory neurotransmitters include:

  • Function: Excitatory neurotransmitters promote the generation of an electrical signal called an action potential in the receiving neuron, while inhibitory neurotransmitters prevent the generation of an action potential.
  • Effects on Neurons: Excitatory neurotransmitters increase the likelihood that a neuron will fire an action potential, while inhibitory neurotransmitters have the opposite effect, reducing the likelihood of a neuron firing an action potential.
  • Examples: Some common excitatory neurotransmitters include acetylcholine, glutamate, and dopamine (depending on the receptors present). Inhibitory neurotransmitters include gamma-aminobutyric acid (GABA) and glycine.
  • Receptors: Whether a neurotransmitter is excitatory or inhibitory depends on the receptor it binds to.

Neurotransmitters play a vital role in nearly every function in the body, from muscle movement to emotional responses. Imbalances in excitatory and inhibitory neurotransmitters can lead to various health issues, and medications often work by increasing or decreasing the amount or action of specific neurotransmitters.

Comparative Table: Excitatory vs Inhibitory Neurotransmitters

Excitatory and inhibitory neurotransmitters are chemical messengers that play crucial roles in transmitting signals across synapses in the nervous system. They have different functions and effects on the target cells they interact with. Here is a comparison between excitatory and inhibitory neurotransmitters:

Property Excitatory Neurotransmitters Inhibitory Neurotransmitters
Function Stimulate the brain, promote action potentials Balance brain stimulation, prevent excessive firing, and create negative membrane potential
Examples Glutamate, Acetylcholine GABA (gamma-aminobutyric acid)
Effect on Membrane Potential Depolarize the membrane potential, generating a net positive and creating an action potential Hyperpolarize the membrane potential, keeping it farther from the threshold potential to generate an action potential

Excitatory neurotransmitters, such as glutamate and acetylcholine, stimulate the brain and promote the generation of action potentials. On the other hand, inhibitory neurotransmitters, like GABA (gamma-aminobutyric acid), help balance brain stimulation by preventing excessive firing and creating a negative membrane potential. This balance between excitatory and inhibitory neurotransmitters is essential for maintaining the proper functioning of the nervous system.