What is the Difference Between Effexor and Effexor xr?

Effexor and Effexor XR are both antidepressant medications containing the active ingredient venlafaxine, which is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). The main difference between the two formulations is the release mechanism and dosing frequency:

• Effexor (Venlafaxine Immediate Release): This formulation is taken two to three times a day with food. It has a shorter half-life of 5 hours.
• Effexor XR (Venlafaxine Extended Release): This formulation is taken once a day, in the morning or evening, with food. It has a longer half-life of 13-14 hours.

Effexor XR is typically prescribed over Effexor Regular/Immediate because it has a less activating effect and a better side effect profile, improving tolerability and reducing nausea. Both formulations treat the same conditions, such as major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. However, the extended-release version may require a longer time to show effects, usually around 6 weeks.

Comparative Table: Effexor vs Effexor xr

Effexor and Effexor XR are both antidepressant medications containing the active ingredient venlafaxine, but they have some differences in their formulations and usage. Here is a table comparing the two:

Both Effexor and Effexor XR belong to a drug class called serotonin-norepinephrine reuptake inhibitors (SNRIs). Effexor XR is designed to release the drug slowly in the body over time, which is why it is taken once per day. Your doctor will likely start you on a low dose and adjust it over time to reach the right amount, ultimately prescribing the smallest dosage that provides the desired effect.