What is the Difference Between Diphenhydramine and Doxylamine?

Diphenhydramine and doxylamine are both antihistamines commonly used as sleep aids. They work similarly and have similar side effects, but there are some differences between them:

1. Duration: Doxylamine stays in your system longer than diphenhydramine, which means it may be more likely to cause next-day drowsiness. Diphenhydramine is eliminated quickly from the body, and most individuals don't experience any hangover effect.
2. Sedation: Doxylamine provides stronger sedative effects and is more likely to provide deep sleep for people with more severe insomnia. Diphenhydramine, on the other hand, is an over-the-counter antihistamine that is often used as a nighttime sleep aid and typically takes longer to take effect than doxylamine.
3. Price: In general, diphenhydramine is less expensive than doxylamine.
4. Ratings: Doxylamine has an average rating of 6.5 out of 10 from a total of 231 ratings on Drugs.com, with 55% of reviewers reporting a positive effect. Diphenhydramine has an average rating of 5.4 out of 10 from a total of 527 ratings on Drugs.com, with 43% of reviewers reporting a positive effect.

Before taking any medication, it is important to consult your doctor about your symptoms and any potential side effects you could experience. This will help you find the best medication for your needs, whether it's doxylamine or diphenhydramine.

Comparative Table: Diphenhydramine vs Doxylamine

Diphenhydramine and doxylamine are both antihistamines used to treat allergic reactions, motion sickness, and as sleep aids. Here is a table highlighting the differences between the two medications:

Clinical studies have shown that doxylamine is more effective as a sleep aid than diphenhydramine. However, it is essential to consult with a doctor before taking any medication to determine the best option for your specific needs.