What is the Difference Between Diclofenac Sodium and Diclofenac Potassium?

Diclofenac sodium and diclofenac potassium are both salts of the non-steroidal anti-inflammatory drug (NSAID) diclofenac. The main differences between them are:

1. Absorption and Onset of Action: Diclofenac potassium has a faster absorption rate and a quicker onset of action compared to diclofenac sodium. Mean peak plasma diclofenac concentrations are attained after 30 to 54 minutes for diclofenac potassium, while it takes 2 to 4 hours for diclofenac sodium. This makes diclofenac potassium more suitable for acute pain.
2. Solubility: Diclofenac potassium has greater water solubility than diclofenac sodium.
3. Sodium Content: Diclofenac sodium has a tendency to retain salt and water in the body, which can predispose patients to cardiovascular events. Diclofenac potassium is preferred in patients with cardiovascular diseases.
4. Dosage Forms: Diclofenac sodium is often found in sustained-release dosage forms, while diclofenac potassium is available in dispersible and powder dosage forms.

Both diclofenac salts are NSAIDs and should be used with caution in patients with hypertension, as they can lead to the onset of new hypertension or worsening of preexisting hypertension. Blood pressure should be monitored closely during the initiation of NSAID treatment.

Comparative Table: Diclofenac Sodium vs Diclofenac Potassium

Here is a table comparing the differences between Diclofenac Sodium and Diclofenac Potassium:

Both Diclofenac Sodium and Diclofenac Potassium are nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and reduce inflammation. The main difference between the two is the rate of absorption and the onset of action. Diclofenac Potassium has a faster onset of action, making it more useful for acute pain.