What is the Difference Between Cubicin and Cubicin RF?

Cubicin and Cubicin RF are both antibacterial injectables indicated for the treatment of complicated skin and skin structure infections, as well as Staphylococcus aureus bloodstream infections, including those with right-sided infective endocarditis. The major differences between Cubicin and Cubicin RF are related to reconstitution and storage properties:

• Storage: Cubicin RF can be stored at both room temperature and refrigerated temperatures, while Cubicin requires refrigerated storage.
• Reconstitution: Cubicin requires 0.9% sodium chloride as a diluent for reconstitution, whereas Cubicin RF uses sterile or bacteriostatic water.
• In-use Shelf Life: Once reconstituted with sterile water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 1 day and 3 days if refrigerated. If reconstituted with bacteriostatic water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 2 days and 3 days if refrigerated.

Both Cubicin and Cubicin RF are available in a 500 mg per vial strength. The active ingredient in both formulations is the same, but the formulations themselves are not identical.

Comparative Table: Cubicin vs Cubicin RF

Cubicin and Cubicin RF are both formulations of the antibiotic daptomycin, but they differ in storage properties and reconstitution. Here is a table summarizing the differences between Cubicin and Cubicin RF:

Both Cubicin and Cubicin RF are used to treat complicated skin and skin structure infections (cSSSI) and Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis in adult patients. However, Cubicin RF has improved storage and reconstitution properties compared to the original Cubicin formulation.