What is the Difference Between Cortisone and Hydrocortisone?

Cortisone and hydrocortisone are both corticosteroids, but they have some differences in their potency, formulation, and usage. Here are the main differences between cortisone and hydrocortisone:

1. Potency: Hydrocortisone is a moderately potent corticosteroid. In comparison, cortisone is less potent. Cortisone is an inactive prodrug that requires conversion in the liver to hydrocortisone, which can then produce anti-inflammatory effects.
2. Formulation: Hydrocortisone is available as an oral tablet, topical cream, topical lotion, topical ointment, and rectal suppository. On the other hand, cortisone is only available as an oral tablet and sometimes under its brand name, Cortone.
3. Conversion: Cortisone requires conversion in the liver to hydrocortisone before it becomes active. This conversion also means that cortisone is not active topically.
4. Usage: Due to its moderate anti-inflammatory potency, hydrocortisone is a useful topical treatment with less marked side effects. Both hydrocortisone and cortisone have relatively high glucocorticoid activity, which can result in fluid retention and make them unsuitable for long-term use.

In summary, cortisone and hydrocortisone are both corticosteroids with some differences in their potency, formulation, and usage. Hydrocortisone is a moderately potent corticosteroid available in various forms, while cortisone is less potent and requires conversion in the liver to become active.

Comparative Table: Cortisone vs Hydrocortisone

Cortisone and hydrocortisone are both corticosteroids, but they have some differences in their properties and usage. Here is a comparison between the two:

Both cortisone and hydrocortisone are used to treat skin conditions and have anti-inflammatory effects. However, cortisone requires conversion in the liver to hydrocortisone and is not active topically, while hydrocortisone is available in various formulations and has moderate anti-inflammatory potency, making it useful for topical use.