What is the Difference Between Codeine and Hydrocodone?

Codeine and hydrocodone are both opioid medications used to treat pain, but they have different potencies and uses. Here are the main differences between the two:

1. Potency: Hydrocodone is considered more powerful than codeine, so it is used for moderate to moderately severe pain, while codeine is typically prescribed for mild to moderately severe pain.
2. Chemical Structure: Codeine is a naturally occurring opiate, while hydrocodone is a synthetic opioid.
3. Metabolism: Codeine converts into morphine when it enters the brain, while hydrocodone breaks down into norhydrocodone and hydromorphone.
4. Availability: Codeine is available as an immediate-release medication, while hydrocodone can be found in combination with other drugs like acetaminophen.
5. Side Effects: Both drugs have similar side effects, such as constipation, sedation, and nausea. However, some side effects may be more intense or more likely with one drug over the other.
6. Addiction Potential: Both codeine and hydrocodone can be addictive, and their misuse can lead to substance abuse and dependency.

Both drugs are prescribed for pain relief and carry an FDA boxed warning for overdose risk. Your doctor will decide which medication is best for you based on your symptoms and the cause of your pain.

Comparative Table: Codeine vs Hydrocodone

Here is a table comparing the differences and similarities between codeine and hydrocodone:

Codeine and hydrocodone are both opioid pain relievers, but they have differences in their origin, potency, and common uses. Codeine is a naturally occurring opioid derived from the opium poppy and is generally prescribed for moderate pain and cough suppression. On the other hand, hydrocodone is a semi-synthetic opioid and is considered more potent than codeine, making it suitable for treating severe pain. Both drugs have similar side effects and carry an FDA warning for overdose risk.