What is the Difference Between Anhydrous and Monohydrate?

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The difference between anhydrous and monohydrate lies in the presence of water in the chemical compounds.

  • Anhydrous: Anhydrous means "without water." Chemicals in their anhydrous form do not contain any water. They may be used in reactions that require anhydrous conditions, and they are typically obtained by boiling or using substances that absorb water.
  • Monohydrate: Monohydrate means "containing one water molecule." Chemicals in their monohydrate form have one water molecule per formula unit. The number of water molecules a substance molecule has is written as "chemical formula. n H2O," where "n" gives the number of water molecules. If the compound is monohydrated, "n" is equal to one.

The anhydrous and monohydrate forms of chemicals may differ in their reactivity, color, and phase. For example, citric acid can exist as either the anhydrous form (C6H8O7) or as the monohydrate form (C6H8O7.H2O).

Comparative Table: Anhydrous vs Monohydrate

Here is a table comparing the differences between anhydrous and monohydrate forms of chemicals:

Property Anhydrous Monohydrate
Definition Without water; contains no water molecules Contains one water molecule per formula unit
Chemical Formula No water molecules in the formula Chemical formula followed by ".n H2O", where "n" is the number of water molecules, which is 1 for monohydrate
Reactivity May differ from monohydrate form May differ from anhydrous form
Color May differ from monohydrate form May differ from anhydrous form
Phase May differ from monohydrate form May differ from anhydrous form
Preparation Obtained by evaporating water (e.g., boiling), using a substance that absorbs water, or using molecular sieves Obtained by crystallization from cold water

Anhydrous and monohydrate forms of chemicals can have different properties, such as reactivity, color, and phase. Anhydrous chemicals are water-free, while monohydrate chemicals contain one water molecule per formula unit. To obtain an anhydrous form, water can be removed by boiling, using a substance that absorbs water, or using molecular sieves. Monohydrate forms can be prepared by crystallization from cold water.