What is the Difference Between African and American Trypanosomiasis?

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African trypanosomiasis, also known as sleeping sickness, and American trypanosomiasis, also known as Chagas disease, are both caused by Trypanosoma parasites but have distinct differences:

  1. Causative parasites: African trypanosomiasis is caused by Trypanosoma brucei parasites, while American trypanosomiasis is caused by Trypanosoma cruzi parasites.
  2. Transmission: African trypanosomiasis is transmitted by the tsetse fly (Glossina), while American trypanosomiasis is transmitted by the triatomine or 'kissing' bug.
  3. Geographical distribution: African trypanomiasis occurs in 36 countries in sub-Saharan Africa, with around 10,000 new cases reported each year. American trypanosomiasis is found in Latin America.
  4. Clinical presentation: Both diseases can result in long-term morbidity and mortality if left untreated. African trypanosomiasis is characterized by neurological problems, while American trypanosomiasis is associated with cardiac issues.
  5. Diagnosis: Diagnosing both African and American trypanosomiasis depends on clinical history, serologic testing, and confirmation by direct visualization of organisms.
  6. Treatment: Both diseases are mainly treated through anti-parasitic drugs. The control and elimination of these diseases are a worldwide effort, with local governments of endemic areas playing a crucial role in implementing screening and treatment measures.

Comparative Table: African vs American Trypanosomiasis

African and American trypanosomiasis are two distinct diseases caused by parasitic protozoa of the genus Trypanosoma. Here is a table highlighting the differences between the two:

Feature African Trypanosomiasis American Trypanosomiasis
Causative Agent Trypanosoma brucei Trypanosoma cruzi
Disease Name Sleeping Sickness Chagas' Disease
Geographic Distribution Sub-Saharan Africa South and Central America
Vector Tsetse fly (Glossina) Triatomine bug (Triatominae)
Mode of Transmission Blood (vector) Blood-to-blood contact (vector)
Clinical Manifestations Early stage: Fever, headache, malaise, and lymphadenopathy
Late stage: Neuropsychiatric symptoms, such as changes in behavior, personality, and cognition
Early stage: Fever, fatigue, body aches, and rash
Late stage (chronic phase): Cardiac and gastrointestinal complications
Diagnosis Physical examination and blood testing Physical examination and blood testing
Treatment Medications, corticosteroids, and surgery for digestive tract-related complications Medications and management of complications
Prevention Control of tsetse fly population, surveillance, and early treatment Control of triatomine bug population, surveillance, and early treatment
Vaccine None available None available

Both diseases are transmitted to humans through a particular fly or bug, and they can be diagnosed through physical examination and blood testing. Control and elimination efforts for both diseases depend on local government cooperation, surveillance, and early treatment.